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However, no clinical human trials have been conducted yet to investigate the efficacy of tesofensine as a treatment option.

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The critical caveat: rodent fat metabolism differs substantially from human fat metabolism

This stepwise titration lets you monitor tolerance while gradually reaching the effective dosing levels observed in preclinical research [1] [4]

Since decreased Parasutterella relative abundance may accompany increased stress 80,81 , the increased Parasutterella relative abundance that occurred in this study following diet switch likely arose from the weight loss-mediated negative energy state