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doi: 10.1056/NEJMc0805011 27 NozawaA.FujimotoR.MatsuokaH.TsuboiT.TozawaY

Emerging evidence shows that Mn porphyrin-based SOD mimics can enhance radiation response to cancer cells, while they protect normal cells from radiation damage

A recent study reported that PI3K pathway repression triggered the activity of the histone-lysine N-methyltransferase 2D (KMTD2), which leads to the activation of ER in breast cancer cells (201)

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(2) Evidence Level classifies evidence as Direct (experimental direct validation), Indirect (inferred from related mechanisms), or Speculative (logical deduction without direct experimental support)