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Using the prize-collecting Steiner tree algorithm, it searches the PPMI interactome to find an optimum subnetwork that connects the input metabolite peaks via their putative identities and other metabolites and proteins that were not detected in the experiments

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After EGCG pretreatment, endothelial cells could induce the expression of membrane-type-1 matrix metalloproteinase (MT1-MMP), which promoted endothelial cell migration, and Cav-1, which caused tube formation, was significantly decreased, suggesting that EGCG inhibits angiogenesis (131)

These findings suggest that CIT amplifies HIIT-related metabolic remodeling and that metabolites such as arginine and selected triglyceride species may serve as biomarkers of enhanced cardiometabolic adaptation (37)

Exclusion criteria were as follows: (1) gastrointestinal bleeding