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Runs alongside glycolysis, branching from the same starting material (glucose-6-phosphate) into a parallel set of reactions that yield NADPH and biosynthetic intermediates

doi: 10.1016/S0014-2999(02)02359-2

As a novel disease with protean manifestations, it has pushed the scientific community into a frenzy to find a cure

PubMed, Purves, Dale, et al

TMA-containing compound assay Trimethylamine-containing compounds were extracted from 50 l of plasma, 50 l of whole liver homogenate or from 100 l of whole brain homogenate (without the cerebellum and olfactory bulbs) by adding 10 volumes of ACN and spiking the samples with 5 l of IS mix containing 12 M d9-TMAO (CIL), 649 nM d9-TMA (CDN Isotopes), 6 M d3-L-carnitine (CIL), 329 nM d9-crotonobetaine (see Koeth et al., 2014) and 5 M d9-TML (Santa Cruz Biotechnology) at the beginning of the extraction