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Although primarily regarded as a gas-exchange organ, the lung demonstrates remarkable metabolic activity, continuously enduring high oxidative stress and substantial circulatory demands

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3 The onset and development of cuproptosis 3.1 Cuproptosis Recently, a novel form of copper-dependent cell death, reliant on mitochondrial respiration, has been identified and termed cuproptosis (Tsvetkov et al., 2022)

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Conclusion Vitamin C shows good results as an antibacterial and anti-biofilm agent in vitro and in vivo alone or combined with antibiotics

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As both bevacizumab and TMZ damage mitochondria (155), these drugs will contribute further to tumor cell reliance on fermentation metabolism thus increasing microenvironment acidification ( Figure 3A )

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