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Carnitine is transported into the muscle cell by a OCTN2, and it was demonstrated that with carnitine supplementation in the presence of high insulin concentrations a 15% increase in muscle carnitine can be obtained (1)

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Physical exercise and particular nutrients, including CIT and leucine, have demonstrated efficacy in upregulating the signaling pathways of PGC-1, SIRT1, and AMPK, thereby facilitating mitochondrial turnover and alleviating oxidative stress (74)

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