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In addition, it has been shown that IgA-deficient mice exhibited persistent intestinal colonization of Proteobacteria , which, in turn, led to permanent intestinal inflammation and increased susceptibility to neonatal and adult models of intestinal damage [87,88]

Previous antioxidant trials in critical illness, especially sepsis, have largely failed due to challenges in pharmacokinetics, patient selection, and trial design (Table 6)

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In questi casi, la somministrazione dell'amminoacido potrebbe aiutare a trattare sia in bambini che in adulti la tossicit dovuta allacido valproico, anche se non si ancora identificato quale sia il miglior regime di somministrazione