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Acknowledgements This work was supported by Ministero dellIstruzione, dellUniversit e della Ricerca of Italy, Progetto PONRicerca e Competitivit 20072013PON01_01802: Sviluppo di molecole capaci di modulare vie metaboliche intracellulari redoxsensibili per la prevenzione e la cura di patologie infettive, tumorali, neurodegenerative e loro delivery mediante piattaforme nano tecnologiche, and PON01_02512: Ricerca e sviluppo di bioregolatori attivi sui meccanismi epigenetici dei processi infiammatori nelle malattie croniche e degenerative

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The activation of Nrf2 has been proven to enhance the antioxidant capacity of neurons (Sadovnikova et al

A daily intake of 2-4g of L-carnitine is recommended 6

Using jepi-info program for sample size calculation and reviewing results from previous study 8 , sample size of 30 patients were sufficient to explore and achieve the study objectives