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But in MCAS, this activation happens inappropriately, excessively, and often chronically

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Specifically, brain tissue analysis revealed decreased levels of respiratory chain complex I, II, IV, and V suggesting damage to mitochondrial proteins

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Circulating oncometabolite 2-hydroxyglutarate as a potential biomarker for isocitrate dehydrogenase (IDH1/2) mutant cholangiocarcinoma

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Waterson MJ, et al

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I'll get there

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