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Primer pairs are listed in Supplementary Data 2

Notably, overcoming age-related impairments in MCUR1-dependent mtCa uptake enhances mitochondrial metabolism and muscle function, significantly restoring mitochondrial activity and physical performance in aged mice [294]

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In addition, ORF3a was also shown to promote inflammasome assembly through TRAF3-mediated ubiquitination of ASC, while another viral protein, ORF8b seems to interact directly with the leucine-rich repeat domain of NLRP3 to stimulate its activation independent of ion channel activity (94)