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doi: 10.3390/ijms19030907 66 MoXShenXMoXYuFTanWDengZet al

siRNA sequences to knock down Hsf1 are: Antisense1: rCrUrUrGrArUrGrUrUrCrUrCrArArGrGrArGrCrUrGrCrUrCrCrUrG Sense1: rGrGrArGrCrArGrCrUrCrCrUrUrGrArGrArArCrArUrCrAAG Antisense2: rArArGrUrGrGrUrCrArCrUrGrArGrCrUrCrArUrUrCrUrUrGrUrCrC Sense2: rArCrArArGrArArUrGrArGrCrUrCrArGrUrGrArCrCrArCTT Negative control siRNA - IDT catalog no

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A study evaluating the effectiveness of a 45-day VLEKT in improving acne in 31 young women with moderate acne and grade I obesity showed a reduction in markers of oxidative stress, such as reactive oxygen metabolite derivatives (dROMs), and a decrease in pro-inflammatory metabolites, including trimethylamine N-oxide (TMAO)

These metabolites were mainly involved in the metabolism of carnitines, ketone bodies, fatty acids, LPC/PC, tryptophan, bile acids, purines and omeprazole