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The Threshold concept for cancer therapy suggests that tumor cells, with higher inherent ROS levels, can be selectively targeted through pro-oxidant therapy, exploiting their impaired redox homeostasis
10.1016/j.cmet.2018.05.011 Cell Metab
Cancer-associated fibroblasts build and secure the tumor microenvironment
Therefore, the subsequent effects of the JAK/STAT signaling pathway may synergize with other mechanisms and are related to the properties of its upstream ligands
Ann Coll Med Mosul 4:3342, 1973
