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As mentioned earlier, development of the follicle to the preantral stage is gonadotropin independent, and any follicular growth beyond this point will require gonadotropin interaction

10.1126/scitranslmed.3009759 Sci Transl Med

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Furthermore, matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) produced by retinal pigment epithelium (RPE) cells are critically involved in maintaining the homeostasis of matrix components in the eye tissues [61]