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It is believed that symptoms may be explained by the local and intermittent stimuli of afferent sensory fibers, which would be caused by xerosis and hypohidrosis secondary to the functional impairment of adnexal structures such as sebaceous and eccrine glands

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Moreover, lacking functions of either m 6 A methylation or m 6 A recognition leads to a greater increase in the expression of m 6 A retrotransposon RNAs carrying both histone modifications compared with those marked by individual histone modifications (Supplementary Fig

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