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Following a toxic dose of APAP, the conjugation pathways of the liver are overwhelmed and an increased proportion of APAP is metabolized by cytochrome (CYP) P450, predominantly CYP2E1, to the highly reactive metabolite NAPQI (Mitchell et al
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Finally, several peptides from the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were consistently enriched with pathology
Each training session lasted maximally two hours or until a rat acquired 100 pellets
