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Additionally, this treatment alleviated joint inflammation and contributed to a partial restoration of joint mobility in arthritic mice 141 (Fig

177,178 In conclusion, mitochondria activate NLRP3 inflammasome and initiate inflammatory response through diversified mechanisms including mtDNA leakage, ROS production, ATP, mitophagy and interaction with lysosomes

Protective effects were also seen in PM 2.5 -exposed guinea pigs, along with a reduction of chronic cough following melatonin treatment [69]

Zvonic, S., Cornelius, P., Stewart, W