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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Hushpulian DM, Ammal Kaidery N, Ahuja M, Poloznikov AA, Sharma SM, Gazaryan IG, Thomas B: Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

This triggers brain inflammation, leading to symptoms like hyperactivity, seizures, altered consciousness, encephalopathy, coma, and psychomotor issues.79 80,81 Cancer Growth and Metastasis Elevated GGT levels degrade glutathione (GSH), increasing hydrogen sulfide (H2S) production and reducing antioxidant activity

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Mature neurons utilize extracellular cysteine for GSH synthesis, while astrocytes utilize cystine, which is formed by oxidation of two cysteines with a disulfide bond