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Long-term oral exposure to PS-MPs causes significant deficits in learning and memory behaviors in mice (44), PS-MPs accumulate in the hippocampal region, affecting the expression of genes related to neural activity and synaptic proteins, inducing neuroinflammation, reducing the expression of immediate early genes, and altering synaptic protein profiles, ultimately leading to impaired learning and memory (44).In study on zebrafish (Symphysodon aequifasciatus) (45), micro- and nanoplastics were found to induce neurobehavioral toxicity through the brain-gut-microbiota axis

In human astrocytes neurotropic flaviviruses increase autophagy, yet their replication is autophagy-independent

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The cumulative incidence of chronic respiratory disease is around 544.9 million people worldwide with COPD accounting for around 55% of the cases of chronic respiratory disease (GBD Chronic Respiratory Disease Collaborators, 2020)

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