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the gluteal site accommodates larger volumes and may be preferred by providers for weekly or monthly protocols

Systemic administration (injectable or oral), which is less common than topical use and not part of approved or standard applications, would theoretically carry different safety considerations requiring appropriate clinical evaluation, though limited research on parenteral administration in animals has suggested acceptable safety profiles at moderate doses

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Another consideration is that excessive use of glutathione may lead to imbalances in other antioxidants within the body

doi: 10.1016/j.cell.2007.06.044