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Fe-doped and doxorubicin loaded HA@Cu 2-X S-PEG (PHCN) nanomaterials were designed as targeted Fe-PHCN@DOX nano-reactors to maximize the effect of ICD to promote antigen presentation thereby stimulating T cell activation, in addition, Fe-PHCN@DOX can reprogram M2 TAMs into M1 TAMs by alleviating tumor hypoxia, at the same time T cell activation is promoted through blockade of the PD-1/PD-L1 immunosuppressive pathway by anti-PD-L1 nanoantibodies thereby achieving effective antitumor effects (226)

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It scavenges free radicals and ROS, effectively neutralizing and expelling them before they can cause damage to cellular structures

As expected, functional enrichment analysis of RNA-Seq data revealed different immune response profiles depending on the severity of the disease ( Figure 6A and Figure S4 )

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