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Similar to the substituents described for alkyl groups above, exemplary substituents for aryl and heteroaryl groups (as well as their divalent derivatives) are varied and are selected from, for example: halogen, OR, NRR, SR, SiRRR, OC(O)R, C(O)R, CO 2 R, C(O)NRR, OC(O)NRR, NRC(O)R, NRC(O)NRR, NRC(O)OR, NRC(NRRR)NR, NRC(NRR)NRS(O)R, S(O) 2 R, S(O) 2 NRR, NRSO 2 R, CN and NO 2 , R, N 3 , CH(Ph) 2 , fluoro(C 1-4 )alkoxo, and fluoro(C 1-4 )alkyl, in a number ranging from zero to the total number of open valences on aromatic ring system

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Through these PPS delivery system and payment reforms, New York is moving toward its statewide DSRIP goal of reducing avoidable hospital use by 25 percent over the five years of its waiver demonstration

While glutathione typically counters the effects of NAPQI, pregnancy reduces glutathione levels (Figure 1)

NAC has an established safety profile, is readily available and easy to administer, and has a favourable tolerability profile, therefore making it an attractive adjunctive therapy