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Clinical specimens Left-over plasma or RNA samples archived at 80 C were retrospectively selected from three laboratories in different geographic locations: (i) Germans Trias i Pujol University Hospital (Badalona, North-eastern Spain) ( n = 74)

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The solved crystal structure places the active site loop in a conformation which closely resembles the reduced `active state` of human succinic semialdehyde dehydrogenase