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In particolare essa responsabile del trasporto dei grassi a catena lunga allinterno dei mitocondri cellulari che sono la centrale energetica delle cellule

Cytometry 41(2):133138 Whitman M, Downes CP, Keeler M, Keller T, Cantley L (1988) Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

The criteria included assessment of shrinking, exhaustion, weakness, slowness, and low physical activity

Moreover, mitochondrial dysfunction and related oxidative stress can activate the innate branch of the immune system, leading to the release of pro-inflammatory cytokines influencing various depression-related pathophysiological mechanisms: monoaminergic neurotransmission disruption, tryptophan degradation toward neurotoxic catabolites, glutamate-related excitotoxicity, decreased neurotrophic factors and alterations in the hypothalamic-pituitary-adrenal axis [3, 33, 59]

Figure 3 summaries PKC effects in promoting vascular dysfunction leading to diabetic retinopathy (Figure 3)