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J Biol Rhythms 35, 439451

The Maintenance of HypothalamusPituitaryThyroid Axis Homeostasis and its Allostasis-Adaptive Responses Physiology of the HypothalamicPituitaryThyroid Axis The neuroendocrine system, which comprises the hypothalamuspituitary-gland axis, is responsible for the homeostatic regulation of most physiological processes such as reproduction, growth, metabolism, energy balance and response to stress

doi: 10.3390/fermentation9030291 39 LaureysD.BrittonS

GPX4, a downstream target of GSH action, functions as a unique intracellular antioxidant enzyme acting on membrane lipid repair, which is able to directly reduce peroxidized phospholipids produced in cell membranes (88,89), and it converts toxic lipid ROS into non-toxic lipid alcohols with the aid of GSH, which thereby reduces the level of oxidative damage to cells (90)

This recycling of internal iron strictly controls iron homeostasis in cells