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When Piezo1 expression is upregulated, past experiments have shown that small injections of the Piezo1 channel agonist Yoda1 into the BF of mice produce the same pathological manifestations as those of sleep deprivation (Ma et al., 2022)
Especially in the context of oxidative damage, there are iron dependent mechanisms that contribute to cellular degeneration and -synuclein aggregation
doi: 10.1016/j.bbrc.2016.10.086 24 SourkesT
Heliyon 10 , e38698 (2024)
