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Bone Marrow Microenvironment The bone marrow niche in MDS patients exhibits increased inflammatory cytokines, including TNF- and IL-6, which suppress normal hematopoiesis and promote the survival of malignant clones

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However, the disparity between mechanistic promise and clinical maturity has direct implications for patient counselling, trial design, regulatory oversight, and ethical considerations surrounding the off-label and grey-market use of these therapies

Two factors are vital in amelioration of damages on cells and improving a disease that include reducing stress and inhibition of apoptotic cell death