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Participants, with a mean age of 61 years, were randomly assigned to receive twice-weekly injections of either 50 mg of methylcobalamin or a placebo for 16 weeks (about four months)

When stored correctly, they can remain stable for months or even years

Therefore, clinicians need to recognize the neurologic symptoms and signs of vitamin B12 deficiency and specifically seek evidence for this diagnosis if it might explain a patients condition rather than waiting for hematologic evidence of vitamin B12 deficiency to turn up on a complete blood count ordered for that or other purposes

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity

The result may be increased bruising