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In a study at the Cleveland Clinic, researchers found that TMAO produced as a result of gut bacteria metabolism is associated with plaque buildup in arteries throughout the body (a disease called atherosclerosis)

These systemic adaptations highlight why exercise is both therapeutic and preventive across the MASLD spectrum, reinforcing the need to incorporate it into daily routines

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Notably, the statistical comparisons in this paper were only done with cirrhotic patients with AUDs and not with the control population (Amodio et al., 1990)