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[DOI] [PMC free article] [PubMed] [Google Scholar] 204.Huang Y, Xu Z, Xiong S, Sun F, Qin G, Hu G, Wang J, Zhao L, Liang YX, Wu T, et al

Additionally, O-GlcNAcylation is implicated in neuropsychiatric disorders, including schizophrenia (SZ) and major depressive disorder (MDD), though its exact role in these conditions is still under investigation

Reads were aligned to a reference built from Ensembl GRCh38 genome sequences using STAR (v2.6.1d)

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Since it is difficult to modify intrinsic GSH reactivity in the presence of cellular GST, warheads with reduced reactivity are preferred to minimize the non-specific covalent binding burden on proteins, which correlates with the in-vitro reaction rate of the drug and GSH [105,106]