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Although it is consistently shown that TMEM106B knockdown has no significant effects on PGRN mRNA and protein levels [135, 145, 146], overexpression of TMEM106B has been reported to increase extracellular and/or intracellular PGRN levels [61, 135, 136] and reduce PGRN processing into granulins [108] in certain cell lines

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(7) Notably, the copper-containing versions of GHK may also help reduce some potential complications that may negatively impact wound healing, such as colonization of the wound with pathogenic microorganisms

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