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SURMOUNT-1 results (72 weeks, adults with obesity): 5 mg dose: approximately 15% body weight loss 10 mg dose: 19.5% body weight loss 15 mg dose: 22.5% body weight loss Placebo: 3.1% body weight loss At the 15 mg maximum dose, the average participant lost about 52 pounds over 72 weeks

Other antioxidants like vitamin C, or skin-lightening agents like tranexamic acid, vitamin A (retinoids), azelaic acid, etc., have evidence for improving skin tone and might be safer choices depending on your profile

477 However, in another similarly-designed study, training twice a day enhanced mitochondrial efficiency, but did not seem to significantly increase the protein abundance of PGC-1 compared to once a day

There was no significant worsening of renal function of any study participant

Perricone, C., C