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Intraperitoneal administration of BPM31510 (25 mg/kg, b.i.d) resulted in a significant decrease in tumour growth by day 45 after inoculation compared to saline-treated mice (Fig

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474 One-carbon metabolism One-carbon (1C) metabolism formed by three reactions, namely the folate cycle, the methionine cycle, and the trans-sulfuration pathway, is of great importance to nucleotide biosynthesis, amino acid homeostasis, methylation modifications, and redox balance