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These reactions are central to cellular physiology, supporting vital functions such as metabolism, cell signaling, energy production, and detoxification
While mathematical models have been developed to address these important questions, they are theoretical and predicated on assumptions 24

The duration of disease before consultation in the clinic was not standardised

A summary of the in vivo models comprehensive of the main advantages and disadvantages and the principal application in CF research is reported in Supplementary Table S1
