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10.1161/ATVBAHA.109.193375 [DOI] [PubMed] [Google Scholar] 238.Fiorelli S, Porro B, Cosentino N, Di Minno A, Manega CM, Fabbiocchi F, et al

This clinical improvement was corroborated by a marked reduction in interleukin-6 (IL-6) concentrations, decreased expression of TNF- and the NF-B p65 subunit, and the normalization of other key inflammatory biomarkers (255)

It is documented that the activation of SIRT1 stimulates the expression of c-Myc by promoting the degradation of FOXO1 to prevent endothelial cell dysfunction and angiogenesis induced by hyperglycemia [81]

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