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Those KEAP1-binding competitors, such as p21 Cip1/WAF1 and BRCA1, were found interacting with NRF2 and thus block the association of KEAP1 with NRF2 [18, 19]
Human research should explore these links
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However, metabolites such as 5-HT are unable to cross the bloodbrain barrier without the involvement of VNS
