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Although elevated BL are well known for its neurotoxic role, physiological concentration appears to confer protection against neuroinflammation ( 2.2.2.1 BL modulates innate immunity in PD The innate immune system plays a central role in the pathogenesis of PD ( Notably, TLR4 ablation impairs microglial phagocytosis of -Syn, facilitating its pathological accumulation ( In PD, elevated intracellular free Fe 2+ leads to microglial iron overload, driving excessive ROS production, increased release of IL-1 and TNF-, and enhanced -Syn aggregation ( Emerging evidence suggests that BL can abnormally activate TRPM2 channels, leading to pathological calcium influx and microglial overactivation

Gallic acid (GA): a multifaceted biomolecule transmuting the biotechnology era, in Recent developments in microbial technologies

Numerous spectroscopic techniques enable the in vivo or ex vivo detection of such modifications, both quantitatively and qualitatively, through the use of specific biomarkers 3