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A faster and simpler UPLC-MS/MS method for the simultaneous determination of tri-methylamine N-oxide, trimethylamine and dimethylamine in different types of biological samples

10.1016/j.reprotox.2023.108368 47 MoradiM.HashemianM

We identify SLC33A1 , SNX17 , VPS35 , CLN, NPC2, and GRN, six genes with variants causing autosomal dominant forms of neurodegeneration, as genetic regulators of microglial lipid droplet formation, and we further validate the accumulation of LAM in GRN -/- mice, a model for frontotemporal dementia

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In addition, nerve injury appears to suspend the inhibitory modulation exerted by noradrenergic descending pathways, letting facilitatory modulation by serotoninergic descending pathways prevail