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Beyond a certain threshold, higher doses don't produce additional benefits and may actually reduce effectiveness through receptor desensitization

Cells 11 , 47

In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions.3 10 In rodents, doses as low as 0.5mg/kg were found to be effective in delivering these anti-pain effects.25 In a 70kg human, an equivalent dose would be around 5.6mg, though thats likely higher than necessary: pharmaceutical-grade GHK-Cu normally ranges from 0.5 mg to 2.5mg per injection

We often get emails from readers whose blood tests come back with elevated B12 levels

Systematic review of factors affecting the ratios of morphine and its major metabolites