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Three of them were hospitalized because of severe pneumonia, double pulmonary embolism and thrombosis

Upon activation, caspase-1 enzymatically processes the precursor pro-interleukin-1 (pro-IL-1) into its biologically active form, mature IL-1, which is then secreted into the extracellular milieu, triggering a robust inflammatory response ( Moreover, MSU triggers the release of pro-inflammatory cytokines, such as interleukin-6 (IL-6), through the NF-B and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, consequently amplifying the infiltration of inflammatory cells ( Figure 1 )

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[Abstract]2019 Jul 9;28(2):512-525.e6

doi: 10.1038/nrc.2016.85