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Although DHA may reduce estrogen synthesis via cyclooxygenase-2 inhibition, further studies using precise biomarkers of DHA exposure and controlling for obesity-related hormonal and inflammatory pathways are needed to clarify these inconsistencies and determine the direction of the association

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Front Microbiol 13:878049 Karimova G, Pidoux J, Ullmann A, Ladant D (1998) A bacterial two-hybrid system based on a reconstituted signal transduction pathway