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Substrates and non-transportable analogues induce structural rearrangements at the extracellular entrance of the glial glutamate transporter GLT-1/EAAT2

doi: 10.3389/fmed.2025.1538194 Received 20 December 2024 Accepted 22 April 2025 Published 09 May 2025 Volume 12 - 2025 Edited by Claudia Fiorillo, University of Florence, Italy Reviewed by Sabina Galiniak, University of Rzeszw, Poland Juan Luis Santiago, Poland Universitario de Ciudad Real, Spain Hiroki Satooka, Shiga University of Medical Science, Japan Jie Zhang, Kunming University of Science and Technology, China Updates Copyright 2025 Luo, Hu, Zhou, Zhang, Wu and Sun

However, two known MAGE-G1 interactors, E2F1 and p75NTR, were not identified in our experiment

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MNPs were synthesized using the co-precipitation method, whereas -CD was polymerized in the presence of a cross-linker to form PCD