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This model is based on the hypothesis that the transition of DNA methylation state of a CpG over a single cell cycle happens in three steps: 1) DNA is passively demethylated through replication, 2) DNA methylation transitions are mediated by TETs and DNMTs, and 3) DNA methylation transition combination states are merged from both homologous chromosomes

doi: 10.1128/Spectrum.00743-21 [DOI] [PMC free article] [PubMed] [Google Scholar] 94.Lee SH, Takahashi K, Hatakawa Y, Oe T

The drive that brought me to TRT in the first place had vanished, replaced by a weird emotional flatness that I couldn't shake