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Several studies have shown increased rates of colon cancer and prostate cancer associated with the intake of large doses of folic acid
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There may be an increased risk of severe adverse reactions in elderly patients, particularly when complicating conditions exist, e.g., impaired kidney and/or liver function, or concomitant use of other drugs
[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Rao D.N., Takahashi N., Mason R.P
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