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History [edit] The concept of diminishing returns can be traced back to the concerns of early economists such as Johann Heinrich von Thnen, Jacques Turgot, Adam Smith, [11] James Steuart, Thomas Robert Malthus, and [12] David Ricardo

During CRPC development, the tumor undergoes several adaptions counteracting supraphysiological androgen levels, including increased androgen synthesis, AR amplification, AR mutation, AR alternative splicing, MYC overexpression, and hyperactive STAT signaling [113,178,183,184]

doi: 10.1007/978-0-387-75681-3_51 42 ChoiEJTangYLeeCBCheongSHSungSHOhMRet al

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Can controlling the conversion of autophagy function contribute to the treatment of cancer, neurodegenerative diseases, inflammation, cell senescence and cardiovascular diseases