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In the model cytosolic GSH has three fates: it is transported into the blood, there is a net flux to GSSG, and 0.2% is removed per hour corresponding to detoxification reactions and excretion into the bile

This high glucose diet led to a decreased lifespan, reduced healthspan (locomotion), and changes in fat storage

The cells were harvested and then incubated with PI and Annexin V-FITC using an apoptosis detection kit (KGA107, USA) following the instructions

Individual Biology Age, genetics, and baseline epithelial turnover rates affect how quickly renewal and signaling stabilize

10.1016/j.redox.2021.102041 [DOI] [PMC free article] [PubMed] [Google Scholar] 323.Karkhanei B, Talebi Ghane E, Mehri F
