nadph and glutathione protect cells against reactive oxygen derivatives Pathophysiology of species (ROS) Cellular mechanisms controlling oxidative stress.

poor sleep disrupts mitochondrial function, increasing ROS

172 In contrast, mitophagy serves as a preventative strategy against inflammation via eliminating damaged mitochondria and avoiding the production of excess ROS, hence the change in mitophagy will result in the alternation of inflammasome activation

The decrease in viability of all the skin cancer cell lines except for SCC-25 cells implies a possible role of this combination treatment in this type of cancers, although the SCC-25 cells intrinsic resistance should be deepened

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[PubMed] National Institutes of Health