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Therefore, in this review our aim is to bring all IGF-1 information regarding metabolism together with the objective of offering clear insight into the issuethis way clarifying how miss-regulation of the GH/IGF-1/insulin axis can lead to metabolic disorders such as MetS and diabetes

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Yes, fatigue and neurological symptoms can occur before anaemia develops, and some patients have normal haemoglobin levels despite B12 deficiency
