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Wang X, Xu T, Liu R, Wu G, Gu L, Zhang Y, Zhang F, Fu H, Ling Y, Wei X, Luo Y

The knockdown of LDH-A caused liver CD133+ CSCs to produce fewer transcriptional factors (Sox2, Nanog, Oct4) that give rise to stemness characteristics, and their spheroid-formation ability was impaired [11]

Furthermore, during periods of nutrient deprivation, glutamine acquisition can occur through the autophagic degradation of macromolecules [25]

Four protons from the matrix are also pumped into the intermembrane space in the process

Astrocytes also modulate the structure and function of the bloodbrain barrier (BBB), a role that has evolutionary roots in glial-controlled vascular regulation observed in primitive vertebrates, with endothelial cell dominance emerging in higher speices 9,10