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The dose ratios of tesofensine and 5-HTP were 1:1 and 3:1 and the experimental ED 30 values of the combination were determined from the log dose-response curve for each dose ratio using linear regression

Starting at 50mg for 7 days allows baseline NNMT activity to decline gradually, minimizing the metabolic shock of sudden substrate shift

Pathway analysis was performed using the gProfiler online tool

However, since much of the research involved mice models, further studies are needed to confirm the findings and to determine how best to treat people diagnosed with NASH
