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While the precise mechanism of OAT3 in urate transport remains unclear, based on its expression site, it is speculated that it may participate in the uptake of urate in peripheral tubules, contributing to urate secretion, or in moving urate from the basement membrane side into the peritubular capillaries, thus engaging in urate reabsorption (4244)

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Its concentration directly regulates the balance between Th1 and Th2 T-helper cell subtypes and impacts host immunocompetence